MersV1, Main, Exploration, bibRecord, 003F36

PDGF Mediates a Neuron–Astrocyte Interaction in the Developing Retina

Identifieur interne : 003F36 ( Main/Exploration ); précédent : 003F35; suivant : 003F37

PDGF Mediates a Neuron–Astrocyte Interaction in the Developing Retina

Auteurs : Marcus Fruttiger [Royaume-Uni] ; Andrew R. Calver [Royaume-Uni] ; Winfried H. Krüger [États-Unis] ; Hardeep S. Mudhar [Royaume-Uni] ; David Michalovich [Royaume-Uni] ; Nobuyuki Takakura [Japon] ; Shin Ichi Nishikawa [Japon] ; William D. Richardson [Royaume-Uni]

Source :

Neuron [ 0896-6273 ] ; 1996.

RBID : ISTEX:E3EBBD41B275596DE7078035574940E3A8C8429B

English descriptors

Teeft :
- Alon, Apa5, Astrocyte, Astrocyte migration, Astrocyte network, Biol, Blood vessels, Cdna, Cell cycle, Cell migration, Dimeric, Dimeric isoforms, Dmem, Endogenous, Epithelium, Epitope, Experimental procedures, Expression pattern, Extracellular, Facs, Gene promoter, Gfap, Glial, Growth factor, Growth factors, Heldin, Hemizygous, Inner surface, Isoforms, Monoclonal, Monoclonal antibody, Mouse, Mrna, Mudhar, Neural retina, Neuron, Nishikawa, Normal development, Oligonucleotide, Optic, Optic nerve, Optic nerve head, Pdgf, Pdgfr, Phenotype, Plasmid, Polypeptide, Postnatal, Proliferative, Promoter, Receptor, Retina, Retinal, Retinal astrocyte network, Retinal astrocytes, Retinal cells, Retinal vasculature, Retinopathy, Rgcs, Sigma, Soluble extracellular fragment, Supernatant, Transgene, Transgenic, Transgenic animals, Transgenic mice, Transgenic retinae, Vascular, Vascular cells, Vasculature, Vegf, Westermark.

Abstract

Abstract: Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFRα), suggesting that PDGF mediates a paracrine interaction between these cells. To test this, we inhibited PDGF signaling in the eye with a neutralizing anti-PDGFRα antibody or a soluble extracellular fragment of PDGFRα. These treatments inhibited development of the astrocyte network. We also generated transgenic mice that overexpress PDGF-A in RGCs. This resulted in hyperproliferation of astrocytes, which in turn induced excessive vasculogenesis. Thus, PDGF appears to be a link in the chain of cell–cell interactions responsible for matching numbers of neurons, astrocytes, and blood vessels during retinal development.

Url:

https://api.istex.fr/ark:/67375/6H6-82NMDKMX-L/fulltext.pdf

DOI: 10.1016/S0896-6273(00)80244-5

Affiliations:

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Le document en format XML

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<term>Biol</term>
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<term>Cdna</term>
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<term>Proliferative</term>
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<term>Retinal</term>
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<front><div type="abstract" xml:lang="en">Abstract: Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFRα), suggesting that PDGF mediates a paracrine interaction between these cells. To test this, we inhibited PDGF signaling in the eye with a neutralizing anti-PDGFRα antibody or a soluble extracellular fragment of PDGFRα. These treatments inhibited development of the astrocyte network. We also generated transgenic mice that overexpress PDGF-A in RGCs. This resulted in hyperproliferation of astrocytes, which in turn induced excessive vasculogenesis. Thus, PDGF appears to be a link in the chain of cell–cell interactions responsible for matching numbers of neurons, astrocytes, and blood vessels during retinal development.</div>
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PDGF Mediates a Neuron–Astrocyte Interaction in the Developing Retina

PDGF Mediates a Neuron–Astrocyte Interaction in the Developing Retina

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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